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Fig. 2 | BMC Bioinformatics

Fig. 2

From: An integrative methodology based on protein-protein interaction networks for identification and functional annotation of disease-relevant genes applied to channelopathies

Fig. 2

Protein-protein interaction (PPI) network of channelopathies analysed in Stage 2. Each network node represents the protein produced by each single, protein-coding gene locus from the gene dataset of channelopathies. The representation is a circular layout based on the betweenness attribute with undirected edges (other layouts shown in Additional file 10). The node size marks the level of degree and therefore neighbourhood (the larger nodes represent proteins with a higher number of interactions). The node colour shows the level of betweenness and therefore the level of centrality (the warmer the colour of the protein, the shorter path between the two which indicates how important the node is within the wider context of the entire network) [31]. HLA proteins are discarded due to their disconnection from the principal component. The image was generated by Cytoscape [23]

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BMC Bioinformatics

ISSN: 1471-2105

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