From: Variant effect predictions capture some aspects of deep mutational scanning experiments
deleterious SAVs (n = 17,781) | beneficial SAVs (n = 15,200) | |||
---|---|---|---|---|
ρ | MSE | ρ | MSE | |
SNAP2 | 0.41 [0.40, 0.42] | 0.3 [0.30, 0.30] | 0.02 [0.01, 0.04] | 0.23 [0.23, 0.24] |
Envision | 0.1 [0.08, 0.11] | 0.06 [0.06, 0.07] | −0.14 [−0.16, − 0.13] | 0.05 [0.04, 0.05] |
Naïve Conservation | 0.29 [0.27, 0.30] | 0.19 [0.19, 0.19] | −0.08 [− 0.09, − 0.06] | 0.19 [0.19, 0.20] |