A statistical network pre-processing method to improve relevance and significance of gene lists in microarray gene expression studies

Table 3 \(\#U_{DEGs}\) refers to the total number of filtered out up-regulated DEGs, \(\#D_{Reg}G\) is the number of down-regulated genes in each data set

Dataset	\(\#U_{DEGs}\)	\(\#D_{DEGs}\)	\(\#R_{UDEGs}Ext\)	\(\#R_{DDEGs}Ext\)	\(\%Sel_{UDEGs}\)	\(\%Sel_{DDEGs}\)
GSE1297	24	6	2119	1047	0.1077	0.0469
GSE9476	379	350	10,132	11,908	1.7008	0.5343
GSE24739	69	105	4785	5939	0.1263	0.1087
GSE5281	122	185	9113	7013	0.2231	0.1282
GSE16759	5	2	1091	64	0.0091	0.0011
GSE14924	440	124	11,429	4473	0.80473	0.0818

\(\#R_{UDEGs}Ext\) indicates the number of up-regulated genes for each gene that successfully mapped onto the IID network. \(\#R_{DDEGs}Ext\) represents the down regulated genes for each gene that successfully mapped onto the IID network. Finally, \(\%Sel_{DDEGs}\) indicates the percentage of detected relevant genes with respect to the total number of available genes in each data set

ISSN: 1471-2105