Table 6 The first 10 enriched pathways using the list of relevant down regulated DEGs obtained from the AML GSE24739 data set
PathwayName | Pvalue | FDRC | BonfC | \(|lg_{2}(P_{value})|\) | \(|lg_{2}(FDR(P_{value})|\) | \(|lg_{2}Bonf(P_{value})|\) |
|---|---|---|---|---|---|---|
(1) Signaling by interleukins | 8.61E−15 | 8.21E−12 | 8.21E−12 | 46.72 | 36.83 | 36.83 |
(2) Adaptive immune system | 1.66E−14 | 7.92E−12 | 1.58E−11 | 45.78 | 36.88 | 35.88 |
(3) Signaling pathways | 3.88E−14 | 1.23E−11 | 3.70E−11 | 44.55 | 36.24 | 34.65 |
(4) Cell surface interactions at the vascular wall | 1.44E−13 | 3.44E−11 | 1.38E−10 | 42.65 | 34.76 | 32.76 |
(5) Cytokine signaling in immune system | 1.48E−13 | 2.81E−11 | 1.41E−10 | 42.62 | 35.05 | 32.73 |
(6) POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 4.47E−13 | 7.11E−11 | 4.27E−10 | 41.02 | 33.71 | 31.13 |
(7) Signaling by EGFR | 4.47E−13 | 6.10E−11 | 4.27E−10 | 41.02 | 33.93 | 31.13 |
(8) Developmental biology | 5.86E−13 | 6.99E−11 | 5.59E−10 | 40.63 | 33.74 | 30.74 |
(9) Hemostasis | 5.88E−13 | 6.24E−11 | 5.61E−10 | 40.63 | 33.90 | 30.73 |
(10) Transcriptional regulation of pluripotent stem cells | 6.67E−13 | 6.36E−11 | 6.36E−10 | 40.45 | 33.87 | 30.55 |