Selected research articles from the 2016 International Workshop on Computational Network Biology: Modeling, Analysis, and Control (CNB-MAC)

Authors: Byung-Jun Yoon, Xiaoning Qian and Tamer Kahveci

Towards targeted combinatorial therapy design for the treatment of castration-resistant prostate cancer

Prostate cancer is one of the most prevalent cancers in males in the United States and amongst the leading causes of cancer related deaths. A particularly virulent form of this disease is castration-resistant ...

Authors: Osama Ali Arshad and Aniruddha Datta

Combination therapy design for maximizing sensitivity and minimizing toxicity

Design of personalized targeted therapies involve modeling of patient sensitivity to various drugs and drug combinations. Majority of studies evaluate the sensitivity of tumor cells to targeted drugs without m...

Authors: Kevin Matlock, Noah Berlow, Charles Keller and Ranadip Pal

Interpretive time-frequency analysis of genomic sequences

Time-Frequency (TF) analysis has been extensively used for the analysis of non-stationary numeric signals in the past decade. At the same time, recent studies have statistically confirmed the non-stationarity ...

Authors: Hamed Hassani Saadi, Reza Sameni and Amin Zollanvari

Comparison of tissue/disease specific integrated networks using directed graphlet signatures

Analysis of integrated genome-scale networks is a challenging problem due to heterogeneity of high-throughput data. There are several topological measures, such as graphlet counts, for characterization of biol...

Authors: Arzu Burcak Sonmez and Tolga Can

Comprehensive evaluation of RNA-seq quantification methods for linearity

Deconvolution is a mathematical process of resolving an observed function into its constituent elements. In the field of biomedical research, deconvolution analysis is applied to obtain single cell-type or tis...

Authors: Haijing Jin, Ying-Wooi Wan and Zhandong Liu