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BMC Bioinformatics

Volume 8 Supplement 7

Proceedings of the Fourth Annual MCBIOS Conference. Computational Frontiers in Biomedicine

Proceedings

Edited by Dawn Wilkins, Yuriy Gusev, Raja Loganantharaj, Susan Bridges, Stephen Winters-Hilt, Jonathan D Wren (Senior Editor)

Fourth Annual MCBIOS Conference. Computational Frontiers in Biomedicine. Go to conference site.

New Orleans, LA, USA1-3 February 2007

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  1. Content type: Proceedings

    To better understand the response of urinary epithelial (urothelial) cells to Enterococcus faecalis, a uropathogen that exhibits resistance to multiple antibiotics, a genome-wide scan of gene expression was obtai...

    Authors: Mikhail G Dozmorov, Kimberly D Kyker, Ricardo Saban, Nathan Shankar, Arto S Baghdayan, Michael B Centola and Robert E Hurst

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S2

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  2. Content type: Proceedings

    Urine from male Sprague-Dawley rats 25, 40, and 80 days old was analyzed by NMR and UPLC/MS. The effects of data normalization procedures on principal component analysis (PCA) and quantitative analysis of NMR-...

    Authors: Laura K Schnackenberg, Jinchun Sun, Parvaneh Espandiari, Ricky D Holland, Joseph Hanig and Richard D Beger

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S3

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  3. Content type: Proceedings

    Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plants grown in the western United States and i...

    Authors: Nan Mei, Lei Guo, Ruqing Liu, James C Fuscoe and Tao Chen

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S4

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  4. Content type: Proceedings

    As compared with traditional transgene copy number detection technologies such as Southern blot analysis, real-time PCR provides a fast, inexpensive and high-throughput alternative. However, the real-time PCR ...

    Authors: Joshua S Yuan, Jason Burris, Nathan R Stewart, Ayalew Mentewab and C Neal Stewart Jr

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S6

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  5. Content type: Proceedings

    Eisenia fetida, commonly known as red wiggler or compost worm, belongs to the Lumbricidae family of the Annelida phylum. Little is known about its genome sequence although it has been extensively used as a test o...

    Authors: Mehdi Pirooznia, Ping Gong, Xin Guan, Laura S Inouye, Kuan Yang, Edward J Perkins and Youping Deng

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S7

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  6. Content type: Proceedings

    Mean-based clustering algorithms such as bisecting k-means generally lack robustness. Although componentwise median is a more robust alternative, it can be a poor center representative for high dimensional data. ...

    Authors: Yuanyuan Ding, Xin Dang, Hanxiang Peng and Dawn Wilkins

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S8

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  7. Content type: Proceedings

    Nanopore detection is based on observations of the ionic current threading a single, highly stable, nanometer-scale channel. The dimensions are such that small biomolecules and biopolymers (like DNA and peptid...

    Authors: Stephen Winters-Hilt

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S9

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  8. Content type: Proceedings

    Synthetic transcription factors (STFs) promise to offer a powerful new therapeutic against Cancer, AIDS, and genetic disease. Currently, 10% of drugs are of this type, including salicylate and tamoxifen. STFs ...

    Authors: Stephen Winters-Hilt, Amanda Davis, Iftekhar Amin and Eric Morales

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S10

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  9. Content type: Proceedings

    Aptamers are nucleic acids selected for their ability to bind to molecules of interest and may provide the basis for a whole new class of medicines. If the aptamer is simply a dsDNA molecule with a ssDNA overh...

    Authors: Karen Thomson, Iftekhar Amin, Eric Morales and Stephen Winters-Hilt

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S11

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  10. Content type: Proceedings

    A nanopore detector has a nanometer-scale trans-membrane channel across which a potential difference is established, resulting in an ionic current through the channel in the pA-nA range. A distinctive channel ...

    Authors: Matthew Landry and Stephen Winters-Hilt

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S12

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  11. Content type: Proceedings

    The regulation of gene expression is achieved through gene regulatory networks (GRNs) in which collections of genes interact with one another and other substances in a cell. In order to understand the underlyi...

    Authors: Peng Li, Chaoyang Zhang, Edward J Perkins, Ping Gong and Youping Deng

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S13

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  12. Content type: Proceedings

    Ionic current blockade signal processing, for use in nanopore detection, offers a promising new way to analyze single molecule properties, with potential implications for DNA sequencing. The alpha-Hemolysin tr...

    Authors: Alexander Churbanov, Carl Baribault and Stephen Winters-Hilt

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S14

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  13. Content type: Proceedings

    Multiple recent studies have found aberrant expression profiles of microRNAome in human cancers. While several target genes have been experimentally identified for some microRNAs in various tumors, the global ...

    Authors: Yuriy Gusev, Thomas D Schmittgen, Megan Lerner, Russell Postier and Daniel Brackett

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S16

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  14. Content type: Proceedings

    Support Vector Machines (SVMs) provide a powerful method for classification (supervised learning). Use of SVMs for clustering (unsupervised learning) is now being considered in a number of different ways.

    Authors: Stephen Winters-Hilt and Sam Merat

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S18

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  15. Content type: Proceedings

    Hidden Markov Models (HMMs) provide an excellent means for structure identification and feature extraction on stochastic sequential data. An HMM-with-Duration (HMMwD) is an HMM that can also exactly model the ...

    Authors: Stephen Winters-Hilt and Carl Baribault

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S19

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  16. Content type: Proceedings

    The UNO/RIC Nanopore Detector provides a new way to study the binding and conformational changes of individual antibodies. Many critical questions regarding antibody function are still unresolved, questions th...

    Authors: Stephen Winters-Hilt, Eric Morales, Iftekhar Amin and Alexander Stoyanov

    Citation: BMC Bioinformatics 2007 8(Suppl 7):S20

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