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Identification of alcohol preference relevant genes in QTL on mouse chromosome 2

Background

Previously, a quantitative trait loci (QTL) for alcohol preference on chromosome 2 in a C57BL/6IBG (B6) background has been identified. The overlap of two of interval specific congenic recombinant strains (ISCRS) strains reduced the QTL interval into a 3.4 mbp region.

Results

By using the keyword alcohol, we identified a total of 39 genetic elements in the region between markers D2Mit56 and D2Mit10. Among these genetic elements, we found seven with potential function in alcohol preference (Table 1). We then examined the SNPs, insertions and deletions, and gene expression levels of those seven genes.

Table 1 Candidate genes for alcohol preference on Chr 2.

Conclusions

Our current data suggest that the Atf2 and Titin genes are potentially the most alcohol relevant genes. However, further experiments and examination are still needed to confirm their candidacy. Several other candidate genes are also in the process of being identified.

Acknowledgments

Support for this research is partially from the NIAAA (1R01 AA016342). NIH, the Veterans Administration Medical Center, and DNA Discovery Core, University of Tennessee, Memphis, TN.

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Correspondence to Weikuan Gu.

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Wang, L., Jiao, Y., Gibson, G. et al. Identification of alcohol preference relevant genes in QTL on mouse chromosome 2. BMC Bioinformatics 12, A2 (2011). https://doi.org/10.1186/1471-2105-12-S7-A2

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Keywords

  • Alcohol
  • Gene Expression
  • Quantitative Trait Locus
  • Candidate Gene
  • Quantitative Trait