Identification of alcohol preference relevant genes in QTL on mouse chromosome 2
© Wang et al; licensee BioMed Central Ltd. 2011
Published: 5 August 2011
Previously, a quantitative trait loci (QTL) for alcohol preference on chromosome 2 in a C57BL/6IBG (B6) background has been identified. The overlap of two of interval specific congenic recombinant strains (ISCRS) strains reduced the QTL interval into a 3.4 mbp region.
Candidate genes for alcohol preference on Chr 2.
ACTIVATING TRANSCRIPTION FACTOR2
TRANS-ACTING TRANSCRIPTION FACTOR3
PYRUVATE DEHYDROGENASE KINASE, ISOENZYME 1
LIMB AND NEURAL PATTERNS
CHOLINERGIC RECEPTOR, NICOTINIC, ALPHAPOLYPEPTIDE1
ATP SYNTHASE, H+ TRANSPORTING, MITOCHONDRIAL F0 COMPLEX, SUBUNIT C, (SUBUNIT 9), ISOFORM 3
Our current data suggest that the Atf2 and Titin genes are potentially the most alcohol relevant genes. However, further experiments and examination are still needed to confirm their candidacy. Several other candidate genes are also in the process of being identified.
Support for this research is partially from the NIAAA (1R01 AA016342). NIH, the Veterans Administration Medical Center, and DNA Discovery Core, University of Tennessee, Memphis, TN.
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