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BMC Bioinformatics

Open Access

Identification of gene expression profiles associated with prognostic groups of patients with Merkel cell carcinoma

BMC Bioinformatics201415(Suppl 10):P20

https://doi.org/10.1186/1471-2105-15-S10-P20

Published: 29 September 2014

Background

Merkel cell carcinoma (MCC) is an aggressive form of skin cancer mostly caused by the Merkel cell polyomavirus [1]. MCC although rare in incidence is associated with poor prognosis. Gene expression studies (GES) have identified a number of genes that are associated with risk of developing MCC. However, their clinical utility to predict risk, response to treatment, or treatment toxicity, remains undefined. There is a need to better understand the biology of MCC and to develop potential new targets with regard to cancer risk and prognostic value [2]. Gene expression profiling and pathway association analysis on GES data can elucidate relevant biological processes, and identify new candidate target genes.

Materials and methods

We sought to identify differential gene expression and functional associations in MCC. Differentially expressed genes with a P value ≤ 0.05 and a fold change ≥ 2.5 between prognostic groups were identified and pathway association analysis was done for a total of 38 differentially expressed genes from a gene expression profiling study [3] with prognostic groups of MCC patients. The over representation of gene-based associations in each pathway was calculated using Fisher's exact test.

Results

Pathways involved in neuropathic pain signaling, glutamate receptor signaling and synaptic long term potentiation were found to be highly enriched with associations. These results suggest that gene expressions associated with these pathways may contribute to MCC development and prognosis.

Authors’ Affiliations

(1)
Department of Genetics, UAMS

References

  1. Chang Y, Moore PS: Merkel Cell Carcinoma: A virus-induced human cancer. Annu Rev Pathol. 2012, 7: 123-144.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Andea AA, Coit DG, Amin B, Busam KJ: Merkel cell carcinoma histologic features and prognosis. Cancer. 2008, 113 (9): 2549-58.View ArticlePubMedGoogle Scholar
  3. Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi ZB, Juergen D, Becker C, Cleary M, Nghiem P: Transcriptome-wide studies of Merkel Cell Carcinoma and validation of intratumoral CD8 lymphocyte invasion as an independent predictor of survival. J Clin Oncol. 2011, 29 (12): 1539-1546.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Raj and Kadlubar; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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