Volume 12 Supplement 10

Proceedings of the Eighth Annual MCBIOS Conference. Computational Biology and Bioinformatics for a New Decade


Edited by Jonathan D Wren (senior editor), Doris M Kupfer, Edward J Perkins, Susan Bridges, Stephen Winters-Hilt, Mikhail G Dozmorov and Ulisses Braga-Neto

Eighth Annual MCBIOS Conference. Computational Biology and Bioinformatics for a New Decade. Go to conference site.

College Station, TX, USA

1-2 April 2011

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  1. Proceedings

    Selecting a single model or combining multiple models for microarray-based classifier development? – A comparative analysis based on large and diverse datasets generated from the MAQC-II project

    Genomic biomarkers play an increasing role in both preclinical and clinical application. Development of genomic biomarkers with microarrays is an area of intensive investigation. However, despite sustained and...

    Minjun Chen, Leming Shi, Reagan Kelly, Roger Perkins, Hong Fang and Weida Tong

    BMC Bioinformatics 2011 12(Suppl 10):S3

    Published on: 18 October 2011

  2. Proceedings

    HOMER: a human organ-specific molecular electronic repository

    Each organ has a specific function in the body. “Organ-specificity” refers to differential expressions of the same gene across different organs. An organ-specific gene/protein is defined as a gene/protein whos...

    Fan Zhang and Jake Y Chen

    BMC Bioinformatics 2011 12(Suppl 10):S4

    Published on: 18 October 2011

  3. Proceedings

    Evaluation of the coverage and depth of transcriptome by RNA-Seq in chickens

    RNA-Seq is the recently developed high-throughput sequencing technology for profiling the entire transcriptome in any organism. It has several major advantages over current hybridization-based approach such as...

    Ying Wang, Noushin Ghaffari, Charles D Johnson, Ulisses M Braga-Neto, Hui Wang, Rui Chen and Huaijun Zhou

    BMC Bioinformatics 2011 12(Suppl 10):S5

    Published on: 18 October 2011

  4. Proceedings

    Constructing a robust protein-protein interaction network by integrating multiple public databases

    Protein-protein interactions (PPIs) are a critical component for many underlying biological processes. A PPI network can provide insight into the mechanisms of these processes, as well as the relationships amo...

    Venkata-Swamy Martha, Zhichao Liu, Li Guo, Zhenqiang Su, Yanbin Ye, Hong Fang, Don Ding, Weida Tong and Xiaowei Xu

    BMC Bioinformatics 2011 12(Suppl 10):S7

    Published on: 18 October 2011

  5. Proceedings

    Analysis of cancer metabolism with high-throughput technologies

    Recent advances in genomics and proteomics have allowed us to study the nuances of the Warburg effect – a long-standing puzzle in cancer energy metabolism – at an unprecedented level of detail. While modern ne...

    Aleksandra A Markovets and Damir Herman

    BMC Bioinformatics 2011 12(Suppl 10):S8

    Published on: 18 October 2011

  6. Proceedings

    A modified Stokes-Einstein equation for Aβ aggregation

    In all amyloid diseases, protein aggregates have been implicated fully or partly, in the etiology of the disease. Due to their significance in human pathologies, there have been unprecedented efforts towards p...

    Srisairam Achuthan, Bong Jae Chung, Preetam Ghosh, Vijayaraghavan Rangachari and Ashwin Vaidya

    BMC Bioinformatics 2011 12(Suppl 10):S13

    Published on: 18 October 2011

  7. Proceedings

    Validation of an arterial tortuosity measure with application to hypertension collection of clinical hypertensive patients

    Hypertension may increase tortuosity or twistedness of arteries. We applied a centerline extraction algorithm and tortuosity metric to magnetic resonance angiography (MRA) brain images to quantitatively measur...

    Karl T Diedrich, John A Roberts, Richard H Schmidt, Chang-Ki Kang, Zang-Hee Cho and Dennis L Parker

    BMC Bioinformatics 2011 12(Suppl 10):S15

    Published on: 18 October 2011

  8. Proceedings

    An efficient and extensible approach for compressing phylogenetic trees

    Biologists require new algorithms to efficiently compress and store their large collections of phylogenetic trees. Our previous work showed that TreeZip is a promising approach for compressing phylogenetic tre...

    Suzanne J Matthews and Tiffani L Williams

    BMC Bioinformatics 2011 12(Suppl 10):S16

    Published on: 18 October 2011

  9. Proceedings

    Latent Semantic Indexing of PubMed abstracts for identification of transcription factor candidates from microarray derived gene sets

    Identification of transcription factors (TFs) responsible for modulation of differentially expressed genes is a key step in deducing gene regulatory pathways. Most current methods identify TFs by searching for...

    Sujoy Roy, Kevin Heinrich, Vinhthuy Phan, Michael W Berry and Ramin Homayouni

    BMC Bioinformatics 2011 12(Suppl 10):S19

    Published on: 18 October 2011

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