Helliwell RJA, Adams LF, Mitchell MD: Prostaglandin synthases: recent developments and a novel hypothesis. Prostaglandins, Leukotrienes and Essential Fatty Acids 2004, 70: 101–113. 10.1016/j.plefa.2003.04.002
Article
CAS
Google Scholar
William SL: Prostanoid biosynthesis and mechanisms of action. Am J Physiol Renal Physiol 1992, 263: 181–191.
Google Scholar
Murakami M, Nakatani Y, Tanioka T, Kudo I: Prostaglandin E synthase. Prostaglandins Other Lipid Media 2002, 68: 383–99. 10.1016/S0090-6980(02)00043-6
Article
Google Scholar
Watanabe K: Prostaglandin F synthase. Prostaglandins & other Lipid Mediators 2002, 68: 401–407. 10.1016/S0090-6980(02)00044-8
Article
Google Scholar
Kanaoka Y, Urade Y: Hematopoietic prostaglandin D synthase. Leukotrienes and Essential Fatty Acids 2003, 69: 63–167.
Article
Google Scholar
Vane J, Corin RE: Prostacyclin: A Vascular Mediator. Eur J Vasc Endovasc Surg 2003, 26: 571–578. 10.1016/S1078-5884(03)00385-X
Article
CAS
PubMed
Google Scholar
Wang LH, Kulmacz RJ: Thromboxane synthase: structure and function of protein and gene. Prostaglandins & other Lipid Mediators 2002, 68: 409–422. 10.1016/S0090-6980(02)00045-X
Article
Google Scholar
Scholich K, Geisslinger G: Is mPGES-1 a promising target for pain therapy? Trends in Pharmacological Sciences 2006, 27: 399–401. 10.1016/j.tips.2006.06.001
Article
CAS
PubMed
Google Scholar
Berman HM, Westbrook J, Feng G, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Research 2000, 28: 235–242. 10.1093/nar/28.1.235
Article
PubMed Central
CAS
PubMed
Google Scholar
Schneidman-Duhovny D, Inbar Y, Nussinov R, Wolfson HJ: PatchDock and SymmDock: servers for rigid and symmetric docking. Nucleic Acids Res 2005, 33: W363–367. 10.1093/nar/gki481
Article
PubMed Central
CAS
PubMed
Google Scholar
Shatsky M, Shulman-peleg A, Nussinov R, Wolfson HJ: The Multiple Common Point Set Problem and Its Application to Molecule Binding Pattern Detection. Journal of Computational Biology 2006, 13: 407–428. 10.1089/cmb.2006.13.407
Article
CAS
PubMed
Google Scholar
Aritake K, Kado Y, Inoue T, Miyano M, Urade Y: Structural and Functional Characterization of HQL-79, an Orally Selective Inhibitor of Human Hematopoietic Prostaglandin D Synthase. The Journal of Biological Chemistry 2006, 281: 5277–15286. 10.1074/jbc.M506431200
Article
Google Scholar
Yamada T, Komoto J, Watanabe K, Ohmiya Y, Takusagawa F: Crystal Structure and Possible Catalytic Mechanism of Microsomal Prostaglandin E Synthase Type 2(mPGES-2). J Mol Biol 2005, 348: 1163–1176. 10.1016/j.jmb.2005.03.035
Article
CAS
PubMed
Google Scholar
Komoto J, Yamada T, Watanabe K, Woodward DF, Takusagawa F: Prostaglandin F2R Formation from Prostaglandin H2 by Prostaglandin F Synthase (PGFS): Crystal Structure of PGFS Containing Bimatoprost. Biochemistry 2006, 45: 1987–1996. 10.1021/bi051861t
Article
CAS
PubMed
Google Scholar
Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL: Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change. J Biol Chem 2008, 283: 2917–2926. 10.1074/jbc.M707470200
Article
PubMed Central
CAS
PubMed
Google Scholar
Benyamini H, Shulman-Peleg A, Wolfson HJ, Belgorodsky B, Fadeev L, Gozin M: Interaction of C60-Fullerene and Carboxyfullerene with Proteins: Docking and Binding Site Alignment. Bioconjugate Chem 2006, 17: 378–386. 10.1021/bc050299g
Article
CAS
Google Scholar
Inbar Y, Schneidman-Duhovny D, Halperin I, Oron A, Nussinov R, Wolfson HJ: Approaching the CAPRI challenge with an efficient geometry-based docking. Proteins 2005, 60: 217–223. 10.1002/prot.20561
Article
CAS
PubMed
Google Scholar
Gidalevitz T, Biswas C, Ding H, Schneidman-Duhovny D, Wolfson HJ, Stevens F, Radford S, Argon Y: Identification of the N-terminal peptide binding site of glucoseregulated protein 94. J Biol Chem 2004, 279: 16543–16552. 10.1074/jbc.M313060200
Article
CAS
PubMed
Google Scholar
Schneidman-Duhovny D, Inbar Y, Polak V, Shatsky M, Halperin I, Benyamini H, Barzilai A, Dror O, Haspel N, Nussinov R, Wolfson HJ: Taking geometry to its edge: fast unbound rigid (and hinge-bent) docking. Proteins 2003, 52: 107–112. 10.1002/prot.10397
Article
CAS
PubMed
Google Scholar
Brenner SE, Koehl P, Levitt M: The ASTRAL compendium for protein structure and sequence analysis. Nucleic Acids Res 2000, 28: 254–256. 10.1093/nar/28.1.254
Article
PubMed Central
CAS
PubMed
Google Scholar
Chandonia JM, Hon G, Walker NS, Lo Conte L, Koehl P, Levitt M, Brenner SE: The ASTRAL Compendium in 2004. Nucleic Acids Res 2004, 32: D189–192. 10.1093/nar/gkh034
Article
PubMed Central
CAS
PubMed
Google Scholar
Inoue T, Okano Y, Kado Y, Aritake K, Irikura D, Uodome N, Okazaki N, Kinugasa S, Shishitani H, Matsumura H, et al.: First Determination of the Inhibitor Complex Structure of Human Hematopoietic Prostaglandin D Synthase. J Biochem 2004, 135: 279–283. 10.1093/jb/mvh033
Article
CAS
PubMed
Google Scholar
Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, et al.: Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nature structural biology 2003, 10: 291–296. 10.1038/nsb907
Article
CAS
PubMed
Google Scholar
Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, et al.: Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase. Cell 1997, 90: 1085–1095. 10.1016/S0092-8674(00)80374-8
Article
CAS
PubMed
Google Scholar
Huang X, Yan W, Gao D, Tong M, Tai HH, Zhan CG: Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis. Bioorganic & Medicinal Chemistry 2006, 14: 3553–3562. 10.1016/j.bmc.2006.01.010
Article
CAS
Google Scholar
Watanabe K, Ohkubo H, Niwa H, Tanikawa N, Koda N, Ito S, Ohmiya Y: Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. Biochemical and Biophysical Research Communications 2003, 306: 577–581. 10.1016/S0006-291X(03)01025-8
Article
CAS
PubMed
Google Scholar
Suzuki T, Fujii Y, Miyano M, Chen LY, Takahashi T, Watanabe K: cDNA Cloning, Expression, and Mutagenesis Study of Liver-type Prostaglandin F Synthase. The Journal of Biological Chemistry 1999, 274: 1241–248.
Google Scholar
Komoto J, Yamada T, Watanabe K, Takusagawa F: Crystal Structure of Human Prostaglandin F Synthase (AKR1C3). Biochemistry 2004, 43: 2188–2198. 10.1021/bi036046x
Article
CAS
PubMed
Google Scholar
Shyue SK, Ruan KH, Wang LH, Wu KK: Prostacyclin Synthase Active Sites, Identification by moleculer modelling-guided site-directed mutagenesis. The Journal of Biological Chemistry 1997, 272: 3657–3662. 10.1074/jbc.272.6.3657
Article
CAS
PubMed
Google Scholar
Chiang CW, Yeh HC, Wang LH, Chan NL: Crystal Structure of the Human Prostacyclin Synthase. J Mol Biol 2006, 364: 266–274. 10.1016/j.jmb.2006.09.039
Article
PubMed Central
CAS
PubMed
Google Scholar
Yamada T, Takusagawa F: PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme. Biochemistry 2007, 46: 8414–8424. 10.1021/bi700605m
Article
CAS
PubMed
Google Scholar
Wright CS, Alden RA, Kraut J: Structure of subtilisin BPN at 2.5 A resolution. Nature 1969, 221: 235–242. 10.1038/221235a0
Article
CAS
PubMed
Google Scholar
Brok P, Sander C, Valencia A: Convergent evolution of similar enzymatic function on different protein folds: The hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Science 1993, 2: 31–40.
Article
Google Scholar
Park JY, Pillinger MH, Abramson SB: Prostaglandin E2 synthesis and secretion:The role of PGE2 synthases. Clinical Immunology 2006, 119: 229–240. 10.1016/j.clim.2006.01.016
Article
CAS
PubMed
Google Scholar
Ruan KH, Li P, Kulmacz RJ, Wu KK: Characterization of the Structure and Membrane Interaction of NH2-terminal Domain of Thromboxane A Synthase. JBC 1994, 269: 2093–2094.
Google Scholar
Delano WL: The PyMOL Molecular Graphics System. DeLano Scientific LLC, San Carlos, CA; 2002.
Google Scholar
Kanehisa M, Goto S: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res 2000, 28: 27–30. 10.1093/nar/28.1.27
Article
PubMed Central
CAS
PubMed
Google Scholar