Protein translational control and its contribution to oncogenesis revealed by computational methods
© Zhong et al; licensee BioMed Central Ltd. 2015
Published: 28 January 2015
Protein translation is a fundamental biochemical process and the regulation of this process in response to a variety of changes has been demonstrated to play a key role in cellular functional activity. Recently, the translational control of oncogenes is implicated in many cancers .
Computational and statistical methodologies facilitate the discovery of the hallmark of eIF4A-dependent transcripts, namely 5'UTR sequence harbors the 12-mer guanine quartet (CGG)4 motif associated with RNA G-quadruplex (GQ) structures (Figure 1C). Our novel computational tools provide a fast, accurate solution to gain biological insights from Ribo-seq and RNA-seq data.
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