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  1. MicroRNAs are ~17–24 nt. noncoding RNAs found in all eukaryotes that degrade messenger RNAs via RNA interference (if they bind in a perfect or near-perfect complementarity to the target mRNA), or arrest transl...

    Authors: Neil R Smalheiser and Vetle I Torvik
    Citation: BMC Bioinformatics 2004 5:139
  2. The insect exoskeleton or cuticle is a bi-partite composite of proteins and chitin that provides protective, skeletal and structural functions. Little information is available about the molecular structure of ...

    Authors: Christiana K Magkrioti, Ioannis C Spyropoulos, Vassiliki A Iconomidou, Judith H Willis and Stavros J Hamodrakas
    Citation: BMC Bioinformatics 2004 5:138
  3. Mutations in rpoB, the gene encoding the β subunit of DNA-dependent RNA polymerase, are associated with rifampin resistance in Mycobacterium tuberculosis. Several studies have been conducted where minimum inhibit...

    Authors: Michael P Cummings and Mark R Segal
    Citation: BMC Bioinformatics 2004 5:137
  4. Microarray experiments are becoming a powerful tool for clinical diagnosis, as they have the potential to discover gene expression patterns that are characteristic for a particular disease. To date, this probl...

    Authors: Bing Liu, Qinghua Cui, Tianzi Jiang and Songde Ma
    Citation: BMC Bioinformatics 2004 5:136
  5. This paper presents the use of Support Vector Machines (SVMs) for prediction and analysis of antisense oligonucleotide (AO) efficacy. The collected database comprises 315 AO molecules including 68 features eac...

    Authors: Gustavo Camps-Valls, Alistair M Chalk, Antonio J Serrano-López, José D Martín-Guerrero and Erik LL Sonnhammer
    Citation: BMC Bioinformatics 2004 5:135
  6. Novel proteins entering the food chain, for example by genetic modification of plants, have to be tested for allergenicity. Allermatch™ http://​allermatch.​org

    Authors: Mark WEJ Fiers, Gijs A Kleter, Herman Nijland, Ad ACM Peijnenburg, Jan Peter Nap and Roeland CHJ van Ham
    Citation: BMC Bioinformatics 2004 5:133
  7. Peach is being developed as a model organism for Rosaceae, an economically important family that includes fruits and ornamental plants such as apple, pear, strawberry, cherry, almond and rose. The genomics and...

    Authors: Sook Jung, Christopher Jesudurai, Margaret Staton, Zhidian Du, Stephen Ficklin, Ilhyung Cho, Albert Abbott, Jeffrey Tomkins and Dorrie Main
    Citation: BMC Bioinformatics 2004 5:130
  8. The discovery of cis-regulatory modules in metazoan genomes is crucial for understanding the connection between genes and organism diversity. It is important to quantify how comparative genomics can improve co...

    Authors: Saurabh Sinha, Mark D Schroeder, Ulrich Unnerstall, Ulrike Gaul and Eric D Siggia
    Citation: BMC Bioinformatics 2004 5:129
  9. Proteins having similar functions from different sources can be identified by the occurrence in their sequences, a conserved cluster of amino acids referred to as pattern, motif, signature or fingerprint. The ...

    Authors: Anuradha Vivekanandan Giri, Sharmila Anishetty and Pennathur Gautam
    Citation: BMC Bioinformatics 2004 5:127
  10. Thousands of genes in a genomewide data set are tested against some null hypothesis, for detecting differentially expressed genes in microarray experiments. The expected proportion of false positive genes in a...

    Authors: J Aubert, A Bar-Hen, J-J Daudin and S Robin
    Citation: BMC Bioinformatics 2004 5:125

    The Erratum to this article has been published in BMC Bioinformatics 2005 6:42

  11. The prediction of ancestral protein sequences from multiple sequence alignments is useful for many bioinformatics analyses. Predicting ancestral sequences is not a simple procedure and relies on accurate align...

    Authors: Richard J Edwards and Denis C Shields
    Citation: BMC Bioinformatics 2004 5:123
  12. Conserved protein sequence motifs are short stretches of amino acid sequence patterns that potentially encode the function of proteins. Several sequence pattern searching algorithms and programs exist forident...

    Authors: Xinghua Lu, Chengxiang Zhai, Vanathi Gopalakrishnan and Bruce G Buchanan
    Citation: BMC Bioinformatics 2004 5:122
  13. Screening of various gene markers such as single nucleotide polymorphism (SNP) and correlation between these markers and development of multifactorial disease have previously been studied. Here, we propose a s...

    Authors: Yasuyuki Tomita, Shuta Tomida, Yuko Hasegawa, Yoichi Suzuki, Taro Shirakawa, Takeshi Kobayashi and Hiroyuki Honda
    Citation: BMC Bioinformatics 2004 5:120
  14. An important challenge for transcript counting methods such as Serial Analysis of Gene Expression (SAGE), "Digital Northern" or Massively Parallel Signature Sequencing (MPSS), is to carry out statistical analy...

    Authors: Ricardo ZN Vêncio, Helena Brentani, Diogo FC Patrão and Carlos AB Pereira
    Citation: BMC Bioinformatics 2004 5:119
  15. The information theoretic concept of mutual information provides a general framework to evaluate dependencies between variables. In the context of the clustering of genes with similar patterns of expression it...

    Authors: Carsten O Daub, Ralf Steuer, Joachim Selbig and Sebastian Kloska
    Citation: BMC Bioinformatics 2004 5:118
  16. The current progress in sequencing projects calls for rapid, reliable and accurate function assignments of gene products. A variety of methods has been designed to annotate sequences on a large scale. However,...

    Authors: Arunachalam Vinayagam, Rainer König, Jutta Moormann, Falk Schubert, Roland Eils, Karl-Heinz Glatting and Sándor Suhai
    Citation: BMC Bioinformatics 2004 5:116
  17. The nematode Caenorhabditis elegans is widely used for the genetic analysis of neuronal cell biology, development, and behavior. Because traditional methods for evaluating behavioral phenotypes are qualitative an...

    Authors: Zhaoyang Feng, Christopher J Cronin, John H Wittig Jr, Paul W Sternberg and William R Schafer
    Citation: BMC Bioinformatics 2004 5:115
  18. Microarray technologies produced large amount of data. The hierarchical clustering is commonly used to identify clusters of co-expressed genes. However, microarray datasets often contain missing values (MVs) r...

    Authors: Alexandre G de Brevern, Serge Hazout and Alain Malpertuy
    Citation: BMC Bioinformatics 2004 5:114
  19. A necessary step for a genome level analysis of the cellular metabolism is the in silico reconstruction of the metabolic network from genome sequences. The available methods are mainly based on the annotation of ...

    Authors: Jibin Sun and An-Ping Zeng
    Citation: BMC Bioinformatics 2004 5:112
  20. Short oligonucleotide arrays have several probes measuring the expression level of each target transcript. Therefore the selection of probes is a key component for the quality of measurements. However, once pr...

    Authors: Laurent Gautier, Morten Møller, Lennart Friis-Hansen and Steen Knudsen
    Citation: BMC Bioinformatics 2004 5:111
  21. Microarray studies in cancer compare expression levels between two or more sample groups on thousands of genes. Data analysis follows a population-level approach (e.g., comparison of sample means) to identify ...

    Authors: James Lyons-Weiler, Satish Patel, Michael J Becich and Tony E Godfrey
    Citation: BMC Bioinformatics 2004 5:110
  22. Recent technological advances in high-throughput data collection allow for experimental study of increasingly complex systems on the scale of the whole cellular genome and proteome. Gene network models are nee...

    Authors: Bahrad A Sokhansanj, Patrick J Fitch, Judy N Quong and Andrew A Quong
    Citation: BMC Bioinformatics 2004 5:108
  23. The integration of many aspects of protein/DNA structure analysis is an important requirement for software products in general area of structural bioinformatics. In fact, there are too few software packages on...

    Authors: Roberto H Higa, Roberto C Togawa, Arnaldo J Montagner, Juliana CF Palandrani, Igor KS Okimoto, Paula R Kuser, Michel EB Yamagishi, Adauto L Mancini and Goran Neshich
    Citation: BMC Bioinformatics 2004 5:107
  24. A detailed understanding of an RNA's correct secondary and tertiary structure is crucial to understanding its function and mechanism in the cell. Free energy minimization with energy parameters based on the ne...

    Authors: Kishore J Doshi, Jamie J Cannone, Christian W Cobaugh and Robin R Gutell
    Citation: BMC Bioinformatics 2004 5:105
  25. Determination of genetic relatedness among microorganisms provides information necessary for making inferences regarding phylogeny. However, there is little information available on how well the genetic relati...

    Authors: Baozhen Qiao and Ronald M Weigel
    Citation: BMC Bioinformatics 2004 5:102
  26. We establish that the occurrence of protein folds among genomes can be accurately described with a Weibull function. Systems which exhibit Weibull character can be interpreted with reliability theory commonly ...

    Authors: Artem Cherkasov, Shannan J Ho Sui, Robert C Brunham and Steven JM Jones
    Citation: BMC Bioinformatics 2004 5:101
  27. cDNA microarrays are a powerful means to screen for biologically relevant gene expression changes, but are often limited by their ability to detect small changes accurately due to "noise" from random and syste...

    Authors: Bin Yao, Sanjay N Rakhade, Qunfang Li, Sharlin Ahmed, Raul Krauss, Sorin Draghici and Jeffrey A Loeb
    Citation: BMC Bioinformatics 2004 5:99
  28. Defining blocks forming the global protein structure on the basis of local structural regularity is a very fruitful idea, extensively used in description, and prediction of structure from only sequence informa...

    Authors: Dariusz Plewczynski, Leszek Rychlewski, Yuzhen Ye, Lukasz Jaroszewski and Adam Godzik
    Citation: BMC Bioinformatics 2004 5:98
  29. Transposable elements (TE) are mobile genetic entities present in nearly all genomes. Previous work has shown that TEs tend to have a different nucleotide composition than the host genes, either considering co...

    Authors: Olivier Andrieu, Anna-Sophie Fiston, Dominique Anxolabéhère and Hadi Quesneville
    Citation: BMC Bioinformatics 2004 5:94
  30. The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to charact...

    Authors: Luis Sánchez-Pulido, Ana M Rojas, Karel H van Wely, Carlos Martinez-A and Alfonso Valencia
    Citation: BMC Bioinformatics 2004 5:91
  31. Oligonucleotide frequencies were shown to be conserved signatures for bacterial genomes, however, the underlying constraints have yet not been resolved in detail. In this paper we analyzed oligonucleotide usag...

    Authors: Oleg N Reva and Burkhard Tümmler
    Citation: BMC Bioinformatics 2004 5:90

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