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  1. In many microarray experiments, analysis is severely hindered by a major difficulty: the small number of samples for which expression data has been measured. When one searches for differentially expressed gene...

    Authors: Amit Zeisel, Amnon Amir, Wolfgang J Köstler and Eytan Domany
    Citation: BMC Bioinformatics 2010 11:400
    Content type: Research article Published on:

  2. Our current understanding of transcription factor binding sites (TFBSs) in sequenced prokaryotic genomes is very limited due to the lack of an accurate and efficient computational method for the prediction of ...

    Authors: Shaoqiang Zhang, Shan Li, Phuc T Pham and Zhengchang Su
    Citation: BMC Bioinformatics 2010 11:397
    Content type: Methodology article Published on:

  3. In the last decade, biochemical studies have revealed that epigenetic modifications including histone modifications, histone variants and DNA methylation form a complex network that regulate the state of chrom...

    Authors: Xiaojiang Xu, Stephen Hoang, Marty W Mayo and Stefan Bekiranov
    Citation: BMC Bioinformatics 2010 11:396
    Content type: Research article Published on:

  4. Mass spectrometry (MS) coupled with online separation methods is commonly applied for differential and quantitative profiling of biological samples in metabolomic as well as proteomic research. Such approaches...

    Authors: Tomáš Pluskal, Sandra Castillo, Alejandro Villar-Briones and Matej Orešič
    Citation: BMC Bioinformatics 2010 11:395
    Content type: Software Published on:

  21. Authors: Ejike Anyanwu, Kaitlyn Cole, Karlee Driver, Anthony Falcone, Elizabeth Farnsworth, Benjamin Howard, Brittney Howard, Courtney Howard, Rodney King, Jordan Olberding, Mackenzie Perkins, Claire Rinehart, Heidi Sayre, Tyler Scaff, Sarah Schrader, Prasanna Tamarapu Parthasarathy…
    Citation: BMC Bioinformatics 2010 11(Suppl 4):P15
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  24. Authors: Ramy K Aziz, Bruce J Aronow, William L Taylor, Sarah L Rowe, Rita Kansal, Mark J Walker and Malak Kotb
    Citation: BMC Bioinformatics 2010 11(Suppl 4):P12
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  30. Authors: Xusheng Wang, Richa Agarwala, John A Capra, Zugen Chen, Deanna M Church, Daniel C Ciobanu, Zhengsheng Li, Lu Lu, Khyobeni Mozhui, Megan K Mulligan, Stanley F Nelson, Katherine S Pollard, Williams L Taylor, Donald B Thomason and Robert W Williams
    Citation: BMC Bioinformatics 2010 11(Suppl 4):O7
    Content type: Oral presentation Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  38. Authors: Steven JM Jones, Janessa Laskin, Yvonne Y Li, Obi L Griffith, Jianghong An, Mikhail Bilenky, Yaron S Butterfield, Timothee Cezard, Eric Chuah, Richard Corbett, Anthony Fejes, Malachi Griffith, John Yee, Montgomery Martin, Michael Mayo, Nataliya Melnyk…
    Citation: BMC Bioinformatics 2010 11(Suppl 4):O3
    Content type: Oral presentation Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  46. Direct in vivo investigation of human metabolism is complicated by the distinct metabolic functions of various sub-cellular organelles. Diverse micro-environments in different organelles may lead to distinct f...

    Authors: Tong Hao, Hong-Wu Ma, Xue-Ming Zhao and Igor Goryanin
    Citation: BMC Bioinformatics 2010 11:393
    Content type: Research article Published on:

  47. Network co-regulated modules are believed to have the functionality of packaging multiple biological entities, and can thus be assumed to coordinate many biological functions in their network neighbouring regi...

    Authors: Lina Chen, Hong Wang, Liangcai Zhang, Wan Li, Qian Wang, Yukui Shang, Yuehan He, Weiming He, Xu Li, Jingxie Tai and Xia Li
    Citation: BMC Bioinformatics 2010 11:392
    Content type: Research article Published on:

  48. In a time-course microarray experiment, the expression level for each gene is observed across a number of time-points in order to characterize the temporal trajectories of the gene-expression profiles. For man...

    Authors: Insuk Sohn, Kouros Owzar, Stephen L George, Sujong Kim and Sin-Ho Jung
    Citation: BMC Bioinformatics 2010 11:391
    Content type: Methodology article Published on:

  50. Conservation and variation scores are used when evaluating sites in a multiple sequence alignment, in order to identify residues critical for structure or function. A variety of scores are available today but ...

    Authors: Fredrik Johansson and Hiroyuki Toh
    Citation: BMC Bioinformatics 2010 11:388
    Content type: Research article Published on:

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