Skip to main content

Articles

Page 82 of 248

  2. There is a vast need to find clinically applicable protein biomarkers as support in cancer diagnosis and tumour classification. In proteomics research, a number of methods can be used to obtain systemic inform...

    Authors: Lina Hultin Rosenberg, Bo Franzén, Gert Auer, Janne Lehtiö and Jenny Forshed
    Citation: BMC Bioinformatics 2010 11:468
    Content type: Research article Published on:

  3. Linking high-throughput experimental data with biological networks is a key step for understanding complex biological systems. Currently, visualization tools for large metabolic networks often result in a dens...

    Authors: Ming Jia, Suh-Yeon Choi, Dirk Reiners, Eve S Wurtele and Julie A Dickerson
    Citation: BMC Bioinformatics 2010 11:469
    Content type: Software Published on:

  6. The enormous throughput and low cost of second-generation sequencing platforms now allow research and clinical geneticists to routinely perform single experiments that identify tens of thousands to millions of...

    Authors: Amol Carl Shetty, Prashanth Athri, Kajari Mondal, Vanessa L Horner, Karyn Meltz Steinberg, Viren Patel, Tamara Caspary, David J Cutler and Michael E Zwick
    Citation: BMC Bioinformatics 2010 11:471
    Content type: Software Published on:

  7. Most software packages for whole genome association studies are non-graphical, purely text based programs originally designed to run with UNIX-like operating systems. Graphical output is often not intended or ...

    Authors: Steffen Uebe, Francesca Pasutto, Mandy Krumbiegel, Denny Schanze, Arif B Ekici and André Reis
    Citation: BMC Bioinformatics 2010 11:472
    Content type: Software Published on:

  8. Signal transduction events often involve transient, yet specific, interactions between structurally conserved protein domains and polypeptide sequences in target proteins. The identification and validation of ...

    Authors: Khader Shameer, Lalima L Madan, Shivamurthy Veeranna, Balasubramanian Gopal and Ramanathan Sowdhamini
    Citation: BMC Bioinformatics 2010 11:473
    Content type: Software Published on:

  9. Most known eukaryotic genomes contain mobile copied elements called transposable elements. In some species, these elements account for the majority of the genome sequence. They have been subject to many mutati...

    Authors: Sebastien Tempel, Christine Rousseau, Fariza Tahi and Jacques Nicolas
    Citation: BMC Bioinformatics 2010 11:474
    Content type: Research article Published on:

  10. Researchers in systems biology use network visualization to summarize the results of their analysis. Such networks often include unconnected components, which popular network alignment algorithms place arbitra...

    Authors: Miha Štajdohar, Minca Mramor, Blaž Zupan and Janez Demšar
    Citation: BMC Bioinformatics 2010 11:475
    Content type: Research article Published on:

  11. MicroRNAs (miRNAs) are single-stranded non-coding RNAs known to regulate a wide range of cellular processes by silencing the gene expression at the protein and/or mRNA levels. Computational prediction of miRNA...

    Authors: Hui Liu, Dong Yue, Yidong Chen, Shou-Jiang Gao and Yufei Huang
    Citation: BMC Bioinformatics 2010 11:476
    Content type: Research article Published on:

  12. In the study of cancer genomics, gene expression microarrays, which measure thousands of genes in a single assay, provide abundant information for the investigation of interesting genes or biological pathways....

    Authors: Fan Shi, Christopher Leckie, Geoff MacIntyre, Izhak Haviv, Alex Boussioutas and Adam Kowalczyk
    Citation: BMC Bioinformatics 2010 11:477
    Content type: Research article Published on:

  13. Microorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic potential in different ecosystems, we need high...

    Authors: Sébastien Terrat, Eric Peyretaillade, Olivier Gonçalves, Eric Dugat-Bony, Fabrice Gravelat, Anne Moné, Corinne Biderre-Petit, Delphine Boucher, Julien Troquet and Pierre Peyret
    Citation: BMC Bioinformatics 2010 11:478
    Content type: Research article Published on:

  14. Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 ...

    Authors: Carmen M Diez-Rivero, Esther M Lafuente and Pedro A Reche
    Citation: BMC Bioinformatics 2010 11:479
    Content type: Research article Published on:

  15. Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat them as rigid bodies, which may lead to inc...

    Authors: Yu-Shen Liu, Qi Li, Guo-Qin Zheng, Karthik Ramani and William Benjamin
    Citation: BMC Bioinformatics 2010 11:480
    Content type: Research article Published on:

  16. Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predicting microbial phenotypes solely based on genomi...

    Authors: Thomas Lingner, Stefanie Mühlhausen, Toni Gabaldón, Cedric Notredame and Peter Meinicke
    Citation: BMC Bioinformatics 2010 11:481
    Content type: Research article Published on:

  17. The binding of peptide fragments of antigens to class II MHC is a crucial step in initiating a helper T cell immune response. The identification of such peptide epitopes has potential applications in vaccine d...

    Authors: Andrew J Bordner and Hans D Mittelmann
    Citation: BMC Bioinformatics 2010 11:482
    Content type: Research article Published on:

  19. Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the emergence of resistant strains. The outlook...

    Authors: Andrés F Flórez, Daeui Park, Jong Bhak, Byoung-Chul Kim, Allan Kuchinsky, John H Morris, Jairo Espinosa and Carlos Muskus
    Citation: BMC Bioinformatics 2010 11:484
    Content type: Research article Published on:

  22. The aim of this study was to provide a framework for the analysis of visceral obesity and its determinants in women, where complex inter-relationships are observed among lifestyle, nutritional and metabolic pr...

    Authors: Alex Aussem, André Tchernof, Sérgio Rodrigues de Morais and Sophie Rome
    Citation: BMC Bioinformatics 2010 11:487
    Content type: Research article Published on:

  23. A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined with physico-chemical properties of the sit...

    Authors: Paola Bertolazzi, Concettina Guerra and Giampaolo Liuzzi
    Citation: BMC Bioinformatics 2010 11:488
    Content type: Methodology article Published on:

  24. Flux variability analysis is often used to determine robustness of metabolic models in various simulation conditions. However, its use has been somehow limited by the long computation time compared to other co...

    Authors: Steinn Gudmundsson and Ines Thiele
    Citation: BMC Bioinformatics 2010 11:489
    Content type: Software Published on:

  25. Mass spectrometry (MS) is an essential analytical tool in proteomics. Many existing algorithms for peptide detection are based on isotope template matching and usually work at different charge states separatel...

    Authors: Youting Sun, Jianqiu Zhang, Ulisses Braga-Neto and Edward R Dougherty
    Citation: BMC Bioinformatics 2010 11:490
    Content type: Methodology article Published on:

  26. Non-coding RNAs gain more attention as their diverse roles in many cellular processes are discovered. At the same time, the need for efficient computational prediction of ncRNAs increases with the pace of sequ...

    Authors: Peter Raasch, Ulf Schmitz, Nadja Patenge, Julio Vera, Bernd Kreikemeyer and Olaf Wolkenhauer
    Citation: BMC Bioinformatics 2010 11:491
    Content type: Methodology article Published on:

  27. An increase in work on the full text of journal articles and the growth of PubMedCentral have the opportunity to create a major paradigm shift in how biomedical text mining is done. However, until now there ha...

    Authors: K Bretonnel Cohen, Helen L Johnson, Karin Verspoor, Christophe Roeder and Lawrence E Hunter
    Citation: BMC Bioinformatics 2010 11:492
    Content type: Research article Published on:

  46. Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics), the study of small molecules involved in metabolic reactions, is a rapidly expanding 'o...

    Authors: Harriet J Muncey, Rebecca Jones, Maria De Iorio and Timothy MD Ebbels
    Citation: BMC Bioinformatics 2010 11:496
    Content type: Software Published on:

  50. One of the major challenges in biology is the correct identification of promoter regions. Computational methods based on motif searching have been the traditional approach taken. Recent studies have shown that...

    Authors: Charles Bland, Abigail S Newsome and Aleksandra A Markovets
    Citation: BMC Bioinformatics 2010 11(Suppl 6):S17
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    3.0 - 2-year Impact Factor
    4.3 - 5-year Impact Factor
    0.938 - SNIP (Source Normalized Impact per Paper)
    1.100 - SJR (SCImago Journal Rank)

    2023 Speed
    19 days submission to first editorial decision for all manuscripts (Median)
    146 days submission to accept (Median)

    2023 Usage
    5,987,678 downloads
    4,858 Altmetric mentions 

Follow

Sign up for article alerts and news from this journal

BMC Bioinformatics

ISSN: 1471-2105

Contact us