Articles

Analyzing a co-occurrence gene-interaction network to identify disease-gene association

Understanding the genetic networks and their role in chronic diseases (e.g., cancer) is one of the important objectives of biological researchers. In this work, we present a text mining system that constructs ...

Authors: Amira Al-Aamri, Kamal Taha, Yousof Al-Hammadi, Maher Maalouf and Dirar Homouz

Predicting clinically promising therapeutic hypotheses using tensor factorization

Determining which target to pursue is a challenging and error-prone first step in developing a therapeutic treatment for a disease, where missteps are potentially very costly given the long-time frames and hig...

Authors: Jin Yao, Mark R. Hurle, Matthew R. Nelson and Pankaj Agarwal

Genomic prediction of tuberculosis drug-resistance: benchmarking existing databases and prediction algorithms

It is possible to predict whether a tuberculosis (TB) patient will fail to respond to specific antibiotics by sequencing the genome of the infecting Mycobacterium tuberculosis (Mtb) and observing whether the path...

Authors: Tra-My Ngo and Yik-Ying Teo

CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer

Non-coding RNAs (ncRNAs) are emerging as key regulators and play critical roles in a wide range of tumorigenesis. Recent studies have suggested that long non-coding RNAs (lncRNAs) could interact with microRNAs...

Authors: Qiu Xiao, Jiawei Luo, Cheng Liang, Jie Cai, Guanghui Li and Buwen Cao

Shambhala: a platform-agnostic data harmonizer for gene expression data

Harmonization techniques make different gene expression profiles and their sets compatible and ready for comparisons. Here we present a new bioinformatic tool termed Shambhala for harmonization of multiple hum...

Authors: Nicolas Borisov, Irina Shabalina, Victor Tkachev, Maxim Sorokin, Andrew Garazha, Andrey Pulin, Ilya I. Eremin and Anton Buzdin

DeepPVP: phenotype-based prioritization of causative variants using deep learning

Prioritization of variants in personal genomic data is a major challenge. Recently, computational methods that rely on comparing phenotype similarity have shown to be useful to identify causative variants. In ...

Authors: Imane Boudellioua, Maxat Kulmanov, Paul N. Schofield, Georgios V. Gkoutos and Robert Hoehndorf

Estimation of duplication history under a stochastic model for tandem repeats

Tandem repeat sequences are common in the genomes of many organisms and are known to cause important phenomena such as gene silencing and rapid morphological changes. Due to the presence of multiple copies of ...

Authors: Farzad Farnoud, Moshe Schwartz and Jehoshua Bruck

CERENKOV2: improved detection of functional noncoding SNPs using data-space geometric features

We previously reported on CERENKOV, an approach for identifying regulatory single nucleotide polymorphisms (rSNPs) that is based on 246 annotation features. CERENKOV uses the xgboost classifier and is designed...

Authors: Yao Yao, Zheng Liu, Qi Wei and Stephen A. Ramsey

Siberian larch (Larix sibirica Ledeb.) chloroplast genome and development of polymorphic chloroplast markers

The main objectives of this study were sequencing, assembling, and annotation of chloroplast genome of one of the main Siberian boreal forest tree conifer species Siberian larch (Larix sibirica Ledeb.) and detect...

Authors: Eugeniya I. Bondar, Yuliya A. Putintseva, Nataliya V. Oreshkova and Konstantin V. Krutovsky

Stepwise large genome assembly approach: a case of Siberian larch (Larix sibirica Ledeb)

De novo assembling of large genomes, such as in conifers (~ 12–30 Gbp), which also consist of ~ 80% of repetitive DNA, is a very complex and computationally intense endeavor. One of the main problems in assemb...

Authors: Dmitry A. Kuzmin, Sergey I. Feranchuk, Vadim V. Sharov, Alexander N. Cybin, Stepan V. Makolov, Yuliya A. Putintseva, Natalya V. Oreshkova and Konstantin V. Krutovsky

MIGREW: database on molecular identification of genes for resistance in wheat

Population structure of fungal infections in wheat differs between wheat varieties and environments. Taking into account evolution of host-pathogen interactions, genetic diversity of both wheat and fungus must...

Authors: Fedor V. Kazantsev, Ekaterina S. Skolotneva, Vasiliy N. Kelbin, Elena A. Salina and Sergey A. Lashin

Application of the geographic population structure (GPS) algorithm for biogeographical analyses of wild and captive gorillas

The utilization of high resolution genome data has important implications for the phylogeographical evaluation of non-human species. Biogeographical analyses can yield detailed understanding of their populatio...

Authors: Ranajit Das and Priyanka Upadhyai

A new version of the ANDSystem tool for automatic extraction of knowledge from scientific publications with expanded functionality for reconstruction of associative gene networks by considering tissue-specific gene expression

Consideration of tissue-specific gene expression in reconstruction and analysis of molecular genetic networks is necessary for a proper description of the processes occurring in a specified tissue. Currently, ...

Authors: Vladimir A. Ivanisenko, Pavel S. Demenkov, Timofey V. Ivanisenko, Elena L. Mishchenko and Olga V. Saik

Bioinformatics research at BGRS-2018

Authors: Tatiana V. Tatarinova, Ming Chen and Yuriy L. Orlov

Inverse similarity and reliable negative samples for drug side-effect prediction

In silico prediction of potential drug side-effects is of crucial importance for drug development, since wet experimental identification of drug side-effects is expensive and time-consuming. Existing computationa...

Authors: Yi Zheng, Hui Peng, Shameek Ghosh, Chaowang Lan and Jinyan Li

Functional homogeneity and specificity of topological modules in human proteome

Functional modules in protein-protein interaction networks (PPIN) are defined by maximal sets of functionally associated proteins and are vital to understanding cellular mechanisms and identifying disease asso...

Authors: Rama Kaalia and Jagath C. Rajapakse

Identification and analysis of structurally critical fragments in HopS2

Among the diverse roles of the Type III secretion-system (T3SS), one of the notable functions is that it serves as unique nano machineries in gram-negative bacteria that facilitate the translocation of effecto...

Authors: Sapna M. Borah and Anupam Nath Jha

Computational discovery and annotation of conserved small open reading frames in fungal genomes

Small open reading frames (smORF/sORFs) that encode short protein sequences are often overlooked during the standard gene prediction process thus leading to many sORFs being left undiscovered and/or misannotat...

Authors: Shuhaila Mat-Sharani and Mohd Firdaus-Raih

GCAC: galaxy workflow system for predictive model building for virtual screening

Traditional drug discovery approaches are time-consuming, tedious and expensive. Identifying a potential drug-like molecule using high throughput screening (HTS) with high confidence is always a challenging ta...

Authors: Deepak R. Bharti, Anmol J. Hemrom and Andrew M. Lynn

Understanding the evolutionary trend of intrinsically structural disorders in cancer relevant proteins as probed by Shannon entropy scoring and structure network analysis

Malignant diseases have become a threat for health care system. A panoply of biological processes is involved as the cause of these diseases. In order to unveil the mechanistic details of these diseased states...

Authors: Sagnik Sen, Ashmita Dey, Sourav Chowdhury, Ujjwal Maulik and Krishnananda Chattopadhyay

Automated craniofacial landmarks detection on 3D image using geometry characteristics information

Indirect anthropometry (IA) is one of the craniofacial anthropometry methods to perform the measurements on the digital facial images. In order to get the linear measurements, a few definable points on the str...

Authors: Arpah Abu, Chee Guan Ngo, Nur Idayu Adira Abu-Hassan and Siti Adibah Othman

GlyStruct: glycation prediction using structural properties of amino acid residues

Glycation is a one of the post-translational modifications (PTM) where sugar molecules and residues in protein sequences are covalently bonded. It has become one of the clinically important PTM in recent times...

Authors: Hamendra Manhar Reddy, Alok Sharma, Abdollah Dehzangi, Daichi Shigemizu, Abel Avitesh Chandra and Tatushiko Tsunoda

Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum

In the current scenario, designing of world-wide effective malaria vaccine against Plasmodium falciparum remain challenging despite the significant progress has been made in last few decades. Conventional vaccino...

Authors: Manisha Pritam, Garima Singh, Suchit Swaroop, Akhilesh Kumar Singh and Satarudra Prakash Singh

Latent network-based representations for large-scale gene expression data analysis

With the recent advancements in high-throughput experimental procedures, biologists are gathering huge quantities of data. A main priority in bioinformatics and computational biology is to provide system level...

Authors: Wajdi Dhifli, Julia Puig, Aurélien Dispot and Mohamed Elati

Benchmarking of different molecular docking methods for protein-peptide docking

Molecular docking studies on protein-peptide interactions are a challenging and time-consuming task because peptides are generally more flexible than proteins and tend to adopt numerous conformations. There ar...

Authors: Piyush Agrawal, Harinder Singh, Hemant Kumar Srivastava, Sandeep Singh, Gaurav Kishore and Gajendra P. S. Raghava

Development of electronic medical records for clinical and research purposes: the breast cancer module using an implementation framework in a middle income country- Malaysia

Advances in medical domain has led to an increase of clinical data production which offers enhancement opportunities for clinical research sector. In this paper, we propose to expand the scope of Electronic Me...

Authors: Nurul Aqilah Mohd Nor, Nur Aishah Taib, Marniza Saad, Hana Salwani Zaini, Zahir Ahmad, Yamin Ahmad and Sarinder Kaur Dhillon

Drug candidate identification based on gene expression of treated cells using tensor decomposition-based unsupervised feature extraction for large-scale data

Although in silico drug discovery is necessary for drug development, two major strategies, a structure-based and ligand-based approach, have not been completely successful. Currently, the third approach, infer...

Authors: Y-h. Taguchi

EpiMethEx: a tool for large-scale integrated analysis in methylation hotspots linked to genetic regulation

DNA methylation is an epigenetic mechanism of genomic regulation involved in the maintenance of homeostatic balance. Dysregulation of DNA methylation status is one of the driver alterations occurring in neopla...

Authors: Saverio Candido, Giuseppe Alessandro Parasiliti Palumbo, Marzio Pennisi, Giulia Russo, Giuseppe Sgroi, Valentina Di Salvatore, Massimo Libra and Francesco Pappalardo

Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites

Glutarylation, the addition of a glutaryl group (five carbons) to a lysine residue of a protein molecule, is an important post-translational modification and plays a regulatory role in a variety of physiologic...

Authors: Kai-Yao Huang, Hui-Ju Kao, Justin Bo-Kai Hsu, Shun-Long Weng and Tzong-Yi Lee

Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions

Molecular Recognition Features (MoRFs) are short protein regions present in intrinsically disordered protein (IDPs) sequences. MoRFs interact with structured partner protein and upon interaction, they undergo ...

Authors: Ronesh Sharma, Alok Sharma, Ashwini Patil and Tatsuhiko Tsunoda

ENVirT: inference of ecological characteristics of viruses from metagenomic data

Estimating the parameters that describe the ecology of viruses,particularly those that are novel, can be made possible using metagenomic approaches. However, the best-performing existing methods require databa...

Authors: Duleepa Jayasundara, Damayanthi Herath, Damith Senanayake, Isaam Saeed, Cheng-Yu Yang, Yuan Sun, Bill C. Chang, Sen-Lin Tang and Saman K. Halgamuge

Diverse dynamics features of novel protein kinase C (PKC) isozymes determine the selectivity of a fluorinated balanol analogue for PKCε

(−)-Balanol is an ATP-mimicking inhibitor that non-selectively targets protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA). While PKA constantly shows tumor promoting activities, PKC isozym...

Authors: Ari Hardianto, Varun Khanna, Fei Liu and Shoba Ranganathan

BioReader: a text mining tool for performing classification of biomedical literature

Scientific data and research results are being published at an unprecedented rate. Many database curators and researchers utilize data and information from the primary literature to populate databases, form hy...

Authors: Christian Simon, Kristian Davidsen, Christina Hansen, Emily Seymour, Mike Bogetofte Barnkob and Lars Rønn Olsen

Intelligent diagnosis with Chinese electronic medical records based on convolutional neural networks

Benefiting from big data, powerful computation and new algorithmic techniques, we have been witnessing the renaissance of deep learning, particularly the combination of natural language processing (NLP) and de...

Authors: Xiaozheng Li, Huazhen Wang, Huixin He, Jixiang Du, Jian Chen and Jinzhun Wu

GenESysV: a fast, intuitive and scalable genome exploration open source tool for variants generated from high-throughput sequencing projects

High throughput sequencing technologies have been increasingly used in basic genetic research as well as in clinical applications. More and more variants underlying Mendelian and complex diseases are being dis...

Authors: Mohammad Zia, Paul Spurgeon, Adrian Levesque, Thomas Furlani and Jianxin Wang

InTAD: chromosome conformation guided analysis of enhancer target genes

High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable acros...

Authors: Konstantin Okonechnikov, Serap Erkek, Jan O. Korbel, Stefan M. Pfister and Lukas Chavez

Integrating random walk and binary regression to identify novel miRNA-disease association

In the last few decades, cumulative experimental researches have witnessed and verified the important roles of microRNAs (miRNAs) in the development of human complex diseases. Benefitting from the rapid growth...

Authors: Ya-Wei Niu, Guang-Hui Wang, Gui-Ying Yan and Xing Chen

Assessment of weighted topological overlap (wTO) to improve fidelity of gene co-expression networks

For more than a decade, gene expression data sets have been used as basis for the construction of co-expression networks used in systems biology investigations, leading to many important discoveries in a wide ...

Authors: André Voigt and Eivind Almaas

ModelExplorer - software for visual inspection and inconsistency correction of genome-scale metabolic reconstructions

Genome-scale metabolic network reconstructions are low level chemical representations of biological organisms. These models allow the system-level investigation of metabolic phenotypes using a variety of compu...

Authors: Nikolay Martyushenko and Eivind Almaas

A controlled comparison of thickness, volume and surface areas from multiple cortical parcellation packages

Cortical parcellation is an essential neuroimaging tool for identifying and characterizing morphometric and connectivity brain changes occurring with age and disease. A variety of software packages have been d...

Authors: Shadia S. Mikhael and Cyril Pernet

First step toward gene expression data integration: transcriptomic data acquisition with COMMAND>_

Exploring cellular responses to stimuli using extensive gene expression profiles has become a routine procedure performed on a daily basis. Raw and processed data from these studies are available on public dat...

Authors: Marco Moretto, Paolo Sonego, Ana B. Villaseñor-Altamirano and Kristof Engelen

Statistical significance approximation for local similarity analysis of dependent time series data

Local similarity analysis (LSA) of time series data has been extensively used to investigate the dynamics of biological systems in a wide range of environments. Recently, a theoretical method was proposed to a...

Authors: Fang Zhang, Fengzhu Sun and Yihui Luan

Parametric and non-parametric gradient matching for network inference: a comparison

Reverse engineering of gene regulatory networks from time series gene-expression data is a challenging problem, not only because of the vast sets of candidate interactions but also due to the stochastic nature...

Authors: Leander Dony, Fei He and Michael P. H. Stumpf

IMOS: improved Meta-aligner and Minimap2 On Spark

Long reads provide valuable information regarding the sequence composition of genomes. Long reads are usually very noisy which renders their alignments on the reference genome a daunting task. It may take days...

Authors: Mostafa Hadadian Nejad Yousefi, Maziar Goudarzi and Seyed Abolfazl Motahari

PaperBot: open-source web-based search and metadata organization of scientific literature

The biomedical literature is expanding at ever-increasing rates, and it has become extremely challenging for researchers to keep abreast of new data and discoveries even in their own domains of expertise. We i...

Authors: Patricia Maraver, Rubén Armañanzas, Todd A. Gillette and Giorgio A. Ascoli

A deep learning method to more accurately recall known lysine acetylation sites

Lysine acetylation in protein is one of the most important post-translational modifications (PTMs). It plays an important role in essential biological processes and is related to various diseases. To obtain a ...

Authors: Meiqi Wu, Yingxi Yang, Hui Wang and Yan Xu

VAPiD: a lightweight cross-platform viral annotation pipeline and identification tool to facilitate virus genome submissions to NCBI GenBank

With sequencing technologies becoming cheaper and easier to use, more groups are able to obtain whole genome sequences of viruses of public health and scientific importance. Submission of genomic data to NCBI ...

Authors: Ryan C. Shean, Negar Makhsous, Graham D. Stoddard, Michelle J. Lin and Alexander L. Greninger

Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico

The development of sequencing techniques and statistical methods provides great opportunities for identifying the impact of rare genetic variation on complex traits. However, there is a lack of knowledge on th...

Authors: Xinyuan Zhang, Anna O. Basile, Sarah A. Pendergrass and Marylyn D. Ritchie

s-dePooler: determination of polymorphism carriers from overlapping DNA pools

Samples pooling is a method widely used in studies to reduce costs and labour. DNA sample pooling combined with massive parallel sequencing is a powerful tool for discovering DNA variants (polymorphisms) in la...

Authors: Aleksandr Igorevich Zhernakov, Alexey Mikhailovich Afonin, Natalia Dmitrievna Gavriliuk, Olga Mikhailovna Moiseeva and Vladimir Aleksandrovich Zhukov

Correction to: Computational approaches for cancer 2017 workshop overview

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Authors: Sunita Chandrasekaran and Eric Stahlberg