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  2. Body composition (BC) is an important factor in determining the risk of type 2-diabetes and cardiovascular disease. Computed tomography (CT) is a useful imaging technique for studying BC, however manual segmen...

    Authors: Nouman Ahmad, Robin Strand, Björn Sparresäter, Sambit Tarai, Elin Lundström, Göran Bergström, Håkan Ahlström and Joel Kullberg
    Citation: BMC Bioinformatics 2023 24:346
    Content type: Research Published on:

  3. Understanding the Mechanism of Action (MoA) of a compound is an often challenging but equally crucial aspect of drug discovery that can help improve both its efficacy and safety. Computational methods to aid M...

    Authors: Layla Hosseini-Gerami, Rosa Hernansaiz Ballesteros, Anika Liu, Howard Broughton, David Andrew Collier and Andreas Bender
    Citation: BMC Bioinformatics 2023 24:344
    Content type: Software Published on:

  4. Genome-wide association studies (GWASes) aim to identify single nucleotide polymorphisms (SNPs) associated with a given phenotype. A common approach for the analysis of GWAS is single marker analysis (SMA) bas...

    Authors: Shuangshuang Xu, Jacob Williams and Marco A. R. Ferreira
    Citation: BMC Bioinformatics 2023 24:343
    Content type: Research Published on:

  6. Mitochondria are the cell organelles that produce most of the chemical energy required to power the cell's biochemical reactions. Despite being a part of a eukaryotic host cell, the mitochondria contain a sepa...

    Authors: Nirmal Singh Mahar, Rohit Satyam, Durai Sundar and Ishaan Gupta
    Citation: BMC Bioinformatics 2023 24:341
    Content type: Research Published on:

  7. Bisulfite sequencing is a powerful tool for profiling genomic methylation, an epigenetic modification critical in the understanding of cancer, psychiatric disorders, and many other conditions. Raw data generat...

    Authors: Nicholas J. Eagles, Richard Wilton, Andrew E. Jaffe and Leonardo Collado-Torres
    Citation: BMC Bioinformatics 2023 24:340
    Content type: Software Published on:

  9. The human gut microbiome (HGM), consisting of trillions of microorganisms, is crucial to human health. Adverse drug use is one of the most important causes of HGM disorder. Thus, it is necessary to identify dr...

    Authors: Binyou Wang, Jianmin Guo, Xiaofeng Liu, Yang Yu, Jianming Wu and Yiwei Wang
    Citation: BMC Bioinformatics 2023 24:338
    Content type: Research Published on:

  11. Residue Interaction Networks (RINs) map the crystallographic description of a protein into a graph, where amino acids are represented as nodes and non-covalent bonds as edges. Determination and visualization o...

    Authors: Alvise Spanò, Lorenzo Fanton, Davide Pizzolato, Jacopo Moi, Francesco Vinci, Alberto Pesce, Cedrix J. Dongmo Foumthuim, Achille Giacometti and Marta Simeoni
    Citation: BMC Bioinformatics 2023 24:336
    Content type: Software Published on:

  12. Circular RNA (CircRNA) is a type of non-coding RNAs in which both ends are covalently linked. Researchers have demonstrated that many circRNAs can act as biomarkers of diseases. However, traditional experiment...

    Authors: Shiyang Liang, Siwei Liu, Junliang Song, Qiang Lin, Shihong Zhao, Shuaixin Li, Jiahui Li, Shangsong Liang and Jingjie Wang
    Citation: BMC Bioinformatics 2023 24:335
    Content type: Research Published on:

  15. To present an approach that autonomously identifies and selects a self-selective optimal target for the purpose of enhancing learning efficiency to segment infected regions of the lung from chest computed tomo...

    Authors: Peng Du, Xiaofeng Niu, Xukun Li, Chiqing Ying, Yukun Zhou, Chang He, Shuangzhi Lv, Xiaoli Liu, Weibo Du and Wei Wu
    Citation: BMC Bioinformatics 2023 24:332
    Content type: Research Published on:

  16. Over the past several decades, metrics have been defined to assess the quality of various types of models and to compare their performance depending on their capacity to explain the variance found in real-life...

    Authors: Evgueni Jacob, Angélique Perrillat-Mercerot, Jean-Louis Palgen, Adèle L’Hostis, Nicoletta Ceres, Jean-Pierre Boissel, Jim Bosley, Claudio Monteiro and Riad Kahoul
    Citation: BMC Bioinformatics 2023 24:331
    Content type: Research Published on:

  17. The study of de novo variation is important for assessing biological characteristics of new variation and for studies related to human phenotypes. Software programs exist to call de novo variants and programs ...

    Authors: Tychele N. Turner
    Citation: BMC Bioinformatics 2023 24:330
    Content type: Software Published on:

  18. Alcohol use disorder (AUD) causes significant morbidity, mortality, and injuries. According to reports, approximately 5% of all registered deaths in Denmark could be due to AUD. The problem is compounded by th...

    Authors: Ali Ebrahimi, Uffe Kock Wiil, Ruben Baskaran, Abdolrahman Peimankar, Kjeld Andersen and Anette Søgaard Nielsen
    Citation: BMC Bioinformatics 2023 24:329
    Content type: Research Published on:

  19. Longitudinal data on key cancer outcomes for clinical research, such as response to treatment and disease progression, are not captured in standard cancer registry reporting. Manual extraction of such outcomes...

    Authors: Haitham A. Elmarakeby, Pavel S. Trukhanov, Vidal M. Arroyo, Irbaz Bin Riaz, Deborah Schrag, Eliezer M. Van Allen and Kenneth L. Kehl
    Citation: BMC Bioinformatics 2023 24:328
    Content type: Research Published on:

  20. The Earth Biogenome Project has rapidly increased the number of available eukaryotic genomes, but most released genomes continue to lack annotation of protein-coding genes. In addition, no transcriptome data i...

    Authors: Tomáš Brůna, Heng Li, Joseph Guhlin, Daniel Honsel, Steffen Herbold, Mario Stanke, Natalia Nenasheva, Matthis Ebel, Lars Gabriel and Katharina J. Hoff
    Citation: BMC Bioinformatics 2023 24:327
    Content type: Research Published on:

  21. Here we present scSNPdemux, a sample demultiplexing pipeline for single-cell RNA sequencing data using natural genetic variations in humans. The pipeline requires alignment files from Cell Ranger (10× Genomics...

    Authors: John K. L. Wong, Lena Jassowicz, Christel Herold-Mende, Martina Seiffert, Jan-Philipp Mallm, Peter Lichter and Marc Zapatka
    Citation: BMC Bioinformatics 2023 24:326
    Content type: Software Published on:

  22. There are countless possibilities for drug combinations, which makes it expensive and time-consuming to rely solely on clinical trials to determine the effects of each possible drug combination. In order to sc...

    Authors: Jing Chen, Lianlian Wu, Kunhong Liu, Yong Xu, Song He and Xiaochen Bo
    Citation: BMC Bioinformatics 2023 24:325
    Content type: Research Published on:

  23. Understanding the impact of gene interactions on disease phenotypes is increasingly recognised as a crucial aspect of genetic disease research. This trend is reflected by the growing amount of clinical researc...

    Authors: Alexandre Renaux, Chloé Terwagne, Michael Cochez, Ilaria Tiddi, Ann Nowé and Tom Lenaerts
    Citation: BMC Bioinformatics 2023 24:324
    Content type: Research Published on:

  24. Prediction of drug–target interaction (DTI) is an essential step for drug discovery and drug reposition. Traditional methods are mostly time-consuming and labor-intensive, and deep learning-based methods addre...

    Authors: Ying Qian, Xinyi Li, Jian Wu and Qian Zhang
    Citation: BMC Bioinformatics 2023 24:323
    Content type: Research Published on:

  26. The impact of a perturbation, over-expression, or repression of a key node on an organism, can be modelled based on a regulatory and/or metabolic network. Integration of these two networks could improve our gl...

    Authors: Sophie Le Bars, Mathieu Bolteau, Jérémie Bourdon and Carito Guziolowski
    Citation: BMC Bioinformatics 2023 24(Suppl 1):321
    Content type: Research Published on:

    This article is part of a Supplement: Volume 24 Supplement 1

  27. Quantitative analysis of neurite growth and morphology is essential for understanding the determinants of neural development and regeneration, however, it is complicated by the labor-intensive process of measu...

    Authors: Joseph T. Vecchi, Sean Mullan, Josue A. Lopez, Madeline Rhomberg, Annamarie Yamamoto, Annabelle Hallam, Amy Lee, Milan Sonka and Marlan R. Hansen
    Citation: BMC Bioinformatics 2023 24:320
    Content type: Research Published on:

  29. Single-cell RNA sequencing (scRNA-seq) technology has enabled assessment of transcriptome-wide changes at single-cell resolution. Due to the heterogeneity in environmental exposure and genetic background acros...

    Authors: Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang and Xiting Yan
    Citation: BMC Bioinformatics 2023 24:318
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Bioinformatics 2023 24:394

  30. Transposable elements (TEs) are short, mobile DNA elements that are known to play important roles in the genomes of many eukaryotic species. The identification and categorization of these elements is a critica...

    Authors: Shelvasha Burkes-Patton, Elizabeth A. Cooper and Jessica Schlueter
    Citation: BMC Bioinformatics 2023 24:317
    Content type: Software Published on:

  31. Biologists are faced with an ever-changing array of complex software tools with steep learning curves, often run on High Performance Computing platforms. To resolve the tradeoff between analytical sophisticati...

    Authors: Graham Alvare, Abiel Roche-Lima and Brian Fristensky
    Citation: BMC Bioinformatics 2023 24:316
    Content type: Software Published on:

  32. Two types of non-invasive, radiation-free, and inexpensive imaging technologies that are widely employed in medical applications are ultrasound (US) and infrared thermography (IRT). The ultrasound image obtain...

    Authors: Na Zhang, Juan Liu, Yu Jin, Wensi Duan, Ziling Wu, Zhaohui Cai and Meng Wu
    Citation: BMC Bioinformatics 2023 24:315
    Content type: Research Published on:

  42. Since the introduction of next-generation sequencing (NGS) techniques, whole-exome sequencing (WES) and whole-genome sequencing (WGS) have not only revolutionized research, but also diagnostics. The gradual sw...

    Authors: Fréderique Boeykens, Sofie F. M. Bhatti, Luc Peelman and Bart J. G. Broeckx
    Citation: BMC Bioinformatics 2023 24:305
    Content type: Software Published on:

  43. Integrating multi-omics data is fast becoming a powerful approach for predicting disease progression and treatment outcomes. In light of that, we introduce a modified version of the NetRank algorithm, a networ...

    Authors: Ali Al-Fatlawi, Eka Rusadze, Alexander Shmelkin, Negin Malekian, Cigdem Ozen, Christian Pilarsky and Michael Schroeder
    Citation: BMC Bioinformatics 2023 24:304
    Content type: Software Published on:

  44. The growing power and ever decreasing cost of RNA sequencing (RNA-Seq) technologies have resulted in an explosion of RNA-Seq data production. Comparing gene expression values within RNA-Seq datasets is relativ...

    Authors: Alvin Farrel, Peng Li, Sharon Veenbergen, Khushbu Patel, John M. Maris and Warren J. Leonard
    Citation: BMC Bioinformatics 2023 24:303
    Content type: Software Published on:

  45. Single-cell RNA sequencing (scRNA-seq) enables the high-throughput profiling of gene expression at the single-cell level. However, overwhelming dropouts within data may obscure meaningful biological signals. V...

    Authors: Yi Cheng, Xiuli Ma, Lang Yuan, Zhaoguo Sun and Pingzhang Wang
    Citation: BMC Bioinformatics 2023 24:302
    Content type: Research article Published on:

  46. The identification of tumor T cell antigens (TTCAs) is crucial for providing insights into their functional mechanisms and utilizing their potential in anticancer vaccines development. In this context, TTCAs a...

    Authors: Phasit Charoenkwan, Nalini Schaduangrat and Watshara Shoombuatong
    Citation: BMC Bioinformatics 2023 24:301
    Content type: Research Published on:

  47. Modern genome sequencing leads to an ever-growing collection of genomic annotations. Combining these elements with a set of input regions (e.g. genes) would yield new insights in genomic associations, such as ...

    Authors: Sven Berres, Jörg Gromoll, Marius Wöste, Sarah Sandmann and Sandra Laurentino
    Citation: BMC Bioinformatics 2023 24:300
    Content type: Software Published on:

  49. Protein biomarkers of cancer progression and response to therapy are increasingly important for improving personalized medicine. Advanced quantitative pathology platforms enable measurement of protein expressi...

    Authors: Misung Yi, Tingting Zhan, Amy R. Peck, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Yunguang Sun, Hallgeir Rui and Inna Chervoneva
    Citation: BMC Bioinformatics 2023 24:298
    Content type: Research Published on:

  50. To understand genome evolution in a group of microbes, we need to know the timing of events such as duplications, deletions and horizontal transfers. A common approach is to perform a gene-tree / species-tree ...

    Authors: Nuo Liu, Tonatiuh A. Gonzalez, Jacob Fischer, Chan Hong, Michelle Johnson, Ross Mawhorter, Fabrizia Mugnatto, Rachael Soh, Shifa Somji, Joseph S. Wirth, Ran Libeskind-Hadas and Eliot C. Bush
    Citation: BMC Bioinformatics 2023 24:295
    Content type: Software Published on:

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