Advertisement
Page 2 of 199
In biomedical text mining, named entity recognition (NER) is an important task used to extract information from biomedical articles. Previously proposed methods for NER are dictionary- or rule-based methods an...
Citation: BMC Bioinformatics 2019 20:735
Horizontal Gene Transfer (HGT) refers to the transfer of genetic materials between organisms through mechanisms other than parent-offspring inheritance. HGTs may affect human health through a large number of m...
Citation: BMC Bioinformatics 2019 20(Suppl 23):702
This article is part of a Supplement: Volume 20 Supplement 23
The main research topic in this paper is how to compare multiple biological experiments using transcriptome data, where each experiment is measured and designed to compare control and treated samples. Comparis...
Citation: BMC Bioinformatics 2019 20(Suppl 23):667
This article is part of a Supplement: Volume 20 Supplement 23
Identifying splice sites is a necessary step to analyze the location and structure of genes. Two dinucleotides, GT and AG, are highly frequent on splice sites, and many other patterns are also on splice sites ...
Citation: BMC Bioinformatics 2019 20(Suppl 23):652
This article is part of a Supplement: Volume 20 Supplement 23
With recent advances in high-throughput technologies, matrix factorization techniques are increasingly being utilized for mapping quantitative omics profiling matrix data into low-dimensional embedding space, in ...
Citation: BMC Bioinformatics 2019 20(Suppl 23):648
This article is part of a Supplement: Volume 20 Supplement 23
There are many different types of microRNAs (miRNAs) and elucidating their functions is still under intensive research. A fundamental step in functional annotation of a new miRNA is to classify it into charact...
Citation: BMC Bioinformatics 2019 20(Suppl 23):646
This article is part of a Supplement: Volume 20 Supplement 23
Current technologies for understanding the transcriptional reprogramming in cells include the transcription factor (TF) chromatin immunoprecipitation (ChIP) experiments and the TF knockout experiments. The ChI...
Citation: BMC Bioinformatics 2019 20(Suppl 23):630
This article is part of a Supplement: Volume 20 Supplement 23
Studying multiple microRNAs (miRNAs) synergism in gene regulation could help to understand the regulatory mechanisms of complicated human diseases caused by miRNAs. Several existing methods have been presented...
Citation: BMC Bioinformatics 2019 20(Suppl 23):613
This article is part of a Supplement: Volume 20 Supplement 23
Analysis of large genomic datasets along with their accompanying clinical information has shown great promise in cancer research over the last decade. Such datasets typically include thousands of samples, each...
Citation: BMC Bioinformatics 2019 20:732
Genomic prediction is an advanced method for estimating genetic values, which has been widely accepted for genetic evaluation in animal and disease-risk prediction in human. It estimates genetic values with ge...
Citation: BMC Bioinformatics 2019 20:731
Differences in cell-type composition across subjects and conditions often carry biological significance. Recent advancements in single cell sequencing technologies enable cell-types to be identified at the sin...
Citation: BMC Bioinformatics 2019 20(Suppl 19):721
This article is part of a Supplement: Volume 20 Supplement 19
Group B streptococcus (GBS) is an important pathogen that is responsible for invasive infections, including sepsis and meningitis. GBS serotyping is an essential means for the investigation of possible infecti...
Citation: BMC Bioinformatics 2019 20(Suppl 19):703
This article is part of a Supplement: Volume 20 Supplement 19
Protein structural class predicting is a heavily researched subject in bioinformatics that plays a vital role in protein functional analysis, protein folding recognition, rational drug design and other related...
Citation: BMC Bioinformatics 2019 20(Suppl 25):701
This article is part of a Supplement: Volume 20 Supplement 25
Membrane proteins play an important role in the life activities of organisms. Knowing membrane protein types provides clues for understanding the structure and function of proteins. Though various computationa...
Citation: BMC Bioinformatics 2019 20(Suppl 25):700
This article is part of a Supplement: Volume 20 Supplement 25
The recognition of protein interaction sites is of great significance in many biological processes, signaling pathways and drug designs. However, most sites on protein sequences cannot be defined as interface ...
Citation: BMC Bioinformatics 2019 20(Suppl 25):699
This article is part of a Supplement: Volume 20 Supplement 25
Alternative splicing allows the pre-mRNAs of a gene to be spliced into various mRNAs, which greatly increases the diversity of proteins. High-throughput sequencing of mRNAs has revolutionized our ability for t...
Citation: BMC Bioinformatics 2019 20(Suppl 25):698
This article is part of a Supplement: Volume 20 Supplement 25
Along with the development of precision medicine, individual heterogeneity is attracting more and more attentions in clinical research and application. Although the biomolecular reaction seems to be some vario...
Citation: BMC Bioinformatics 2019 20(Suppl 25):697
This article is part of a Supplement: Volume 20 Supplement 25
Protein-protein docking is a valuable computational approach for investigating protein-protein interactions. Shape complementarity is the most basic component of a scoring function and plays an important role ...
Citation: BMC Bioinformatics 2019 20(Suppl 25):696
This article is part of a Supplement: Volume 20 Supplement 25
Imbalanced datasets are commonly encountered in bioinformatics classification problems, that is, the number of negative samples is much larger than that of positive samples. Particularly, the data imbalance ph...
Citation: BMC Bioinformatics 2019 20(Suppl 25):695
This article is part of a Supplement: Volume 20 Supplement 25
The interactions among proteins act as crucial roles in most cellular processes. Despite enormous effort put for identifying protein-protein interactions (PPIs) from a large number of organisms, existing first...
Citation: BMC Bioinformatics 2019 20(Suppl 25):694
This article is part of a Supplement: Volume 20 Supplement 25
Glaucoma is an irreversible eye disease caused by the optic nerve injury. Therefore, it usually changes the structure of the optic nerve head (ONH). Clinically, ONH assessment based on fundus image is one of t...
Citation: BMC Bioinformatics 2019 20(Suppl 25):693
This article is part of a Supplement: Volume 20 Supplement 25
The Copy Number Alterations (CNAs) are discovered to be tightly associated with cancers, so accurately detecting them is one of the most important tasks in the cancer genomics. A series of CNAs detection metho...
Citation: BMC Bioinformatics 2019 20(Suppl 25):692
This article is part of a Supplement: Volume 20 Supplement 25
The association between BIN1 rs744373 variant and Alzheimer’s disease (AD) had been identified by genome-wide association studies (GWASs) as well as candidate gene studies in Caucasian populations. But in East...
Citation: BMC Bioinformatics 2019 20(Suppl 25):691
This article is part of a Supplement: Volume 20 Supplement 25
2′-O-methylation (2′-O-me or Nm) is a post-transcriptional RNA methylation modified at 2′-hydroxy, which is common in mRNAs and various non-coding RNAs. Previous studies revealed the significance of Nm in mult...
Citation: BMC Bioinformatics 2019 20(Suppl 25):690
This article is part of a Supplement: Volume 20 Supplement 25
Accurate identification of potential interactions between drugs and protein targets is a critical step to accelerate drug discovery. Despite many relative experimental researches have been done in the past dec...
Citation: BMC Bioinformatics 2019 20(Suppl 25):689
This article is part of a Supplement: Volume 20 Supplement 25
The occurrence of cotton pests and diseases has always been an important factor affecting the total cotton production. Cotton has a great dependence on environmental factors during its growth, especially clima...
Citation: BMC Bioinformatics 2019 20(Suppl 25):688
This article is part of a Supplement: Volume 20 Supplement 25
Bamboo is a very important forest resource. However, the prolonged vegetative stages and uncertainty of flowering brings difficulties in bamboo flowers sampling. Until now, the flowering mechanism of bamboo is...
Citation: BMC Bioinformatics 2019 20(Suppl 25):687
This article is part of a Supplement: Volume 20 Supplement 25
Predicting miRNA-disease associations (MDAs) is time-consuming and expensive. It is imminent to improve the accuracy of prediction results. So it is crucial to develop a novel computing technology to predict n...
Citation: BMC Bioinformatics 2019 20(Suppl 25):686
This article is part of a Supplement: Volume 20 Supplement 25
Protein structure prediction has always been an important issue in bioinformatics. Prediction of the two-dimensional structure of proteins based on the hydrophobic polarity model is a typical non-deterministic...
Citation: BMC Bioinformatics 2019 20(Suppl 25):685
This article is part of a Supplement: Volume 20 Supplement 25
RNA secondary structure prediction is an important issue in structural bioinformatics, and RNA pseudoknotted secondary structure prediction represents an NP-hard problem. Recently, many different machine-learn...
Citation: BMC Bioinformatics 2019 20(Suppl 25):684
This article is part of a Supplement: Volume 20 Supplement 25
In ab initio protein-structure predictions, a large set of structural decoys are often generated, with the requirement to select best five or three candidates from the decoys. The clustered central structures ...
Citation: BMC Bioinformatics 2019 20(Suppl 25):683
This article is part of a Supplement: Volume 20 Supplement 25
Protein complexes are the cornerstones of many biological processes and gather them to form various types of molecular machinery that perform a vast array of biological functions. In fact, a protein may belong...
Citation: BMC Bioinformatics 2019 20(Suppl 25):682
This article is part of a Supplement: Volume 20 Supplement 25
Cost-sensitive algorithm is an effective strategy to solve imbalanced classification problem. However, the misclassification costs are usually determined empirically based on user expertise, which leads to uns...
Citation: BMC Bioinformatics 2019 20(Suppl 25):681
This article is part of a Supplement: Volume 20 Supplement 25
Protein comparative analysis and similarity searches play essential roles in structural bioinformatics. A couple of algorithms for protein structure alignments have been developed in recent years. However, fac...
Citation: BMC Bioinformatics 2019 20(Suppl 19):662
This article is part of a Supplement: Volume 20 Supplement 19
Drug-drug interactions (DDIs) are a major concern in patients’ medication. It’s unfeasible to identify all potential DDIs using experimental methods which are time-consuming and expensive. Computational method...
Citation: BMC Bioinformatics 2019 20(Suppl 19):661
This article is part of a Supplement: Volume 20 Supplement 19
Single-cell RNA-sequencing (scRNA-seq) is a transformative technology, allowing global transcriptomes of individual cells to be profiled with high accuracy. An essential task in scRNA-seq data analysis is the ...
Citation: BMC Bioinformatics 2019 20(Suppl 19):660
This article is part of a Supplement: Volume 20 Supplement 19
Accurate classification of diffuse gliomas, the most common tumors of the central nervous system in adults, is important for appropriate treatment. However, detection of isocitrate dehydrogenase (IDH) mutation an...
Citation: BMC Bioinformatics 2019 20(Suppl 19):659
This article is part of a Supplement: Volume 20 Supplement 19
Studying structural and functional morphology of small organisms such as monogenean, is difficult due to the lack of visualization in three dimensions. One possible way to resolve this visualization issue is t...
Citation: BMC Bioinformatics 2019 20(Suppl 19):658
This article is part of a Supplement: Volume 20 Supplement 19
Synthetic lethality has attracted a lot of attentions in cancer therapeutics due to its utility in identifying new anticancer drug targets. Identifying synthetic lethal (SL) interactions is the key step toward...
Citation: BMC Bioinformatics 2019 20(Suppl 19):657
This article is part of a Supplement: Volume 20 Supplement 19
A survey of presences and absences of specific species across multiple biogeographic units (or bioregions) are used in a broad area of biological studies from ecology to microbiology. Using binary presence-abs...
Citation: BMC Bioinformatics 2019 20(Suppl 15):644
This article is part of a Supplement: Volume 20 Supplement 15
Super-enhancers (SEs) are clusters of transcriptional active enhancers, which dictate the expression of genes defining cell identity and play an important role in the development and progression of tumors and ...
Citation: BMC Bioinformatics 2019 20(Suppl 15):598
This article is part of a Supplement: Volume 20 Supplement 15
Traditional drug research and development is high cost, time-consuming and risky. Computationally identifying new indications for existing drugs, referred as drug repositioning, greatly reduces the cost and attra...
Citation: BMC Bioinformatics 2019 20(Suppl 15):547
This article is part of a Supplement: Volume 20 Supplement 15
A drug-drug interaction (DDI) is defined as a drug effect modified by another drug, which is very common in treating complex diseases such as cancer. Many studies have evidenced that some DDIs could be an incr...
Citation: BMC Bioinformatics 2019 20(Suppl 15):538
This article is part of a Supplement: Volume 20 Supplement 15
Antimicrobial resistance (AMR) is a major threat to global public health because it makes standard treatments ineffective and contributes to the spread of infections. It is important to understand AMR’s biolog...
Citation: BMC Bioinformatics 2019 20(Suppl 15):535
This article is part of a Supplement: Volume 20 Supplement 15
Chromatin immunoprecipitation sequencing (ChIP-seq) is a technology that combines chromatin immunoprecipitation (ChIP) with next generation of sequencing technology (NGS) to analyze protein interactions with D...
Citation: BMC Bioinformatics 2019 20(Suppl 15):515
This article is part of a Supplement: Volume 20 Supplement 15
Cluster analysis is a core task in modern data-centric computation. Algorithmic choice is driven by factors such as data size and heterogeneity, the similarity measures employed, and the type of clusters sough...
Citation: BMC Bioinformatics 2019 20(Suppl 15):503
This article is part of a Supplement: Volume 20 Supplement 15
The biological network is highly dynamic. Functional relations between genes can be activated or deactivated depending on the biological conditions. On the genome-scale network, subnetworks that gain or lose l...
Citation: BMC Bioinformatics 2019 20(Suppl 15):489
This article is part of a Supplement: Volume 20 Supplement 15
Protein-protein interaction plays a key role in a multitude of biological processes, such as signal transduction, de novo drug design, immune responses, and enzymatic activities. Gaining insights of various bi...
Citation: BMC Bioinformatics 2019 20(Suppl 15):483
This article is part of a Supplement: Volume 20 Supplement 15
Gene is a key step in genome annotation. Ab initio gene prediction enables gene annotation of new genomes regardless of availability of homologous sequences. There exist a number of ab initio gene prediction tool...
Citation: BMC Bioinformatics 2019 20(Suppl 15):482
This article is part of a Supplement: Volume 20 Supplement 15
Cognitive decline has emerged as a significant threat to both public health and personal welfare, and mild cognitive decline/impairment (MCI) can further develop into Dementia/Alzheimer’s disease. While treatm...
Citation: BMC Bioinformatics 2019 20(Suppl 15):481
This article is part of a Supplement: Volume 20 Supplement 15
View featured videos from across the BMC-series journals
Citation Impact
2.511 - 2-year Impact Factor
2.970 - 5-year Impact Factor
0.855 - Source Normalized Impact per Paper (SNIP)
1.374 - SCImago Journal Rank (SJR)
Usage
4,129,368 downloads
Social Media Impact
4446 mentions
Advertisement
